Parties of 10 or more must be guaranteed with a credit card and reserved by calling 573-730-7777. 24 hour cancellation required. 18% gratuity automatically added to parties of 6 or more. While Isle Casino Cape Girardeau makes every effort to review guest requests and comments, please note that these requests are not guaranteed. We cannot hold your reservation for more than 15 minutes beyond your reservation time. For more information, please call 573-730-7777.